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Danish et
al., (2017) reported the synthesis of new sulfonamide compound,
4((4chlorophenylsulfonamido)methyl) cyclohexane carboxylicacid
(C14H18ClNO4S) from 4-chlororbenzene sulfonyl chloride and tranexamic acid at room
temperature by providing basic media. Its
molecular structure was resoluted from
FT-IR, NMR, single-crystal X-ray and elemental analysis. Antimicrobial
screening of these compounds was carried out and results demonstrated that
these compounds are inactive against 4 bacterial strains as well as two fungal
strains, but the leading compound has potential to behave as inhibiting agent
for ?-chymotrypsin.11

Bavadi et
al., (2017) carried out the synthesis of a series of compounds having
sulfonamide moiety which was dihydropyrrol-2-ones. Antibacterial activity
results demonstrated that nearly all compounds showed antibacterial activity
against bacterial species, P. aeruginosa and S. epidermidis. Noticeably
most of the compounds were more active against P. aeruginosa than reference
drug (trimethoprim-sulfamethoxazole), especially one which can probably be an
antibacterial agent.12

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Tabatabaee., et al (2017) reported the synthesis and
characterization of two Schiff bases, N-(2-hydroxy-3-methoxybenzylidene)-4-methylbenzenesulfonohydrazide
and N-(2-hydroxy-3-methoxybenzylidene)-4-nitrobenzenesulfonohydrazide. Antimicrobial
activity of these compounds against gram positive and gram negative bacteria,
which includes Staphylococcus saprophyticus, Staphylococcus epidermidis and Proteus mirabilis, was checked and reported. The antibacterial study was carried out by
using disc diffusion method with a reference standard of Vancomycin and
Trimethoprim /sulfamethoxazole.13

Ghorab et al., (2017) synthesized a new series
of thiourea  N-(2,6-dimethoxypyrimidin-4-yl)-4-(3-(aryl) thioureido)
benzenesulfonamides, which possess sulfonamide moiety. These Fluorinated
pyridine derivatives showed high anti-microbial
activity against gram-positive bacteria.
MIC values of these compounds were also reported along with the docking study
results. Docking study suggested good action as mitogen
activated protein kinase-2 inhibitor. 14

Sonu et al., (2017) conducted a study on sulfonamides and reported the good
antimicrobial activity of 4-Amino-N-(6-methyl-benzothiazole-2-yl)-benzene
sulfonamide derivatives,  4-(Benzyidene-amino)-N-(5-methyl-isoxazol-3yl)benzene
sulfonamide and 4-(3,5-Dimethyl-1H-pyrazol-4-ylamino)-benzene sulfonamide. All these
compounds have sulfonamide group as an inhibitor
of folic acid synthesis in bacteria, which hinders the multiplication of
bacteria and acts as a good antimicrobial
agent against many gram positive and
negative bacteria.15

et al., (2017) studied that a series
of amide derivatives of sulphonamides were manufactured and their antimicrobial
as well as anticonvulsant activities were assessed by using the Cup-plate method and MES model. Some of the
compounds demonstrated good antibacterial  action against E.coli. Two major compounds, 4-(4-Methoxy-phenyl)-4-oxo-N-(4-Sulfomoyl-Phenyl-)butyramide
and 4-(4-chloro-3-methyl-phenyl)-4-oxo-N-(4-sulfamoyl-phenyl)-butyramide
showed prominent inhibitory activity against gram-negative

Varmaghani et al., (2017) synthesized
two different classes of sulfonamides by means of the electrochemical method. The electro-oxidatively generated
4-(4-aminophenyl)-3H-1,2,4-triazole-3,5(4H)-dione on reaction
with arylsulfinic acids gives sulfonamide
derivatives. Direct electrochemical oxidation of 4-(4-nitrophenyl)urazole, in a divided cell in the presence of arylsulfinic
acids was accomplished to synthesize the second series of sulfonamides. Both these
classes of sulfonamides were found effective against E. coli 
aeruginosa , S. aureus , Salmonella Typhi , Aspergillus niger , and Candida albicans  17

Cheptea et al.,
(2017) reported that according to recent researches those compounds which have
Sulfonamide moiety shows different kinds of biological activities which include
antimicrobial activity significantly. Synthesis of new sulfonamides was carried
out by the condensation reaction of 5-nitroindazloe with substituted methyl phenoxy
ester sulphochlorides. Synthesis of 5-nitroindazole sulfonamides was carried out with
high yields. Their chemical structures were verified by using 1H-NMR
and 1 FT-IR  and their
antimicrobial potential were checked and
it was concluded that sulfonamide derivatives of 5-nitroindazole hold noticeable antibacterial activity.18

De Oliveir et al., (2016) derived nine new sulfonamides from carvacol
in good yields (76% to 92%). These
compounds were characterized by using
spectroscopic and spectrometric methods. Three of these compounds showed
tremendous antibacterial activity against drug-resistant
bacteria (S.aureus). Sulfonamide
derivatives of 4-methylaniline and 4-fluoroaniline possess good activity against drug-resistant bacteria, when combined
tetracycline and ampicillin. Best antibacterial results were given by 4-methylaniline derivatives in combination with
erythromycin. Carvacrol in combination with antibiotics is also tested but
showed no effect. .19

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