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According to some animal experiments, Polysorbate 80
has been linked to infertility in mice, an increased risk of blood clots, heart
attack, stroke, heart failure and even the recurrence of cancer. This additive
was indicated by a article in PubMed as a resonable agent of anaphylactic shock
in pregnant women. Moreover, other studies identified that this emulsifier makes
some diseases more dangerous such as Crohn’s disease with symptoms include
abdominal pain, diarrhea, sometimes bloody and weight loss.

Biomedical
Sciences researchers, which is led by Georgia State University, discovered that
Polysorbate 80 disarranged the gut flora, formed suitable condition for growth
of negative flora. This shift of dominance of flora induced the development of
digestive ailments such as ulcerative colitis, Crohn’s disease and inflammatory
bowel diseases. Since this emulsifier were introduced, the incidences of
metabolic syndrome and other types of obesity related health issues that lead
to heart disease , liver disease and diabetes have been on the rise as well.

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In
one study, scientists fed mice with two of the most popular emulsifiers which
are Polysorbate 80 and Carboxymethylcellulose, at high enough doses that it
mimicked the average human consumption. All of the mice had dramatic changes to
their guts including increased inflammation levels. Because their gut flora had
been adjusted, chronic colitis appeared and their immune system responses were
damaged. These mice also generated metabolic syndrome, increased levels of food
consumption, insulin resistance and obesity.

Toxicity
and carcinogenicity studies were conducted by adding Polysorbate 80 in diet to
groups of B6C3F1 mice and F344/N rats of each sex for 14 days, 13 weeks and 2
years. In this research, groups of five mice and five rats of each sex fed by
meals containing 0, 3000, 6000, 12500, 25000 or 50000 ppm Polysorbate 80. In
conclusion, under the conditions of these 2-year feed studies, there was
unclear evidence of carcinogenic activity for polysorbate 80 in male F344/N
rats based on an increased incidence of pheochromocytomas of the adrenal
medulla. The results also showed that there was no presence of carcinogenic
activity for polysorbate 80 in female F344/N rats or in male or female B6C3F1
mice. The addition of polysorbate 80 in diets was associated with ulcers of the
forestomach in female mice and with inflammation and squamous hyperplasia of
the forestomach in male and female mice.  

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